Network pharmacology and molecular docking reveal the multi-target mechanism of cortex moutan in diabetes treatment
Jianting Wei*
The role of Cortex Moutan as a traditional Chinese medicine in treating diabetes mellitus has garnered increasing attention, but its mechanism of action remains understudied. The compounds of C. Moutan were screened from the database according to two pharmacokinetic parameters, and seven potentially active compounds were obtained.
Post-harvest management of millets: A pathway to sustainability and food security
Ruchika Zalpouri*; Baldev Singh Kalsi
Millet utilization, despite nutritional and climate-resilient advantages, is limited by post-harvest constraints. This communication analyses critical challenges, including inadequate processing technology, suboptimal storage, and limited market access. Optimized post-harvest operations, encompassing cleaning, drying, dehusking, and controlled atmosphere storage, are crucial for maintaining millet quality and market value.
Prevalence of zinc deficiency in type 2 diabetic patients: Systematic review
Guy Roussel Takuissu*; Sebastien Kenmoe; Janvier Aimé Youovop; Boris Ronald Tchuente; Mounpou Jafarou; Souriou Soufianou; Gabriel Nama Medoua
Type 2 Diabetes Mellitus (T2DM) is a worldwide health concern that is frequently associated by micronutrient deficiencies, such as zinc. However, the frequency of zinc deficiency in T2DM patients remains little understood. The purpose of this systematic review was to assess the global prevalence of zinc insufficiency among individuals with T2DM.
Thrombospondin 1, obesity and nonalcoholic fatty liver disease
Konstanza Angelova*
The thrombospondin 1 (THBS1 or TSP-1), a subunit of a homotrimeric protein, is a multifunctional adhesive glycoprotein, encoded in humans by THBS1 gene [1]. It is a member of the thrombospondin family of five extracellular matrix proteins. THBS1 is produced and secreted in extracellular space by endothelial cells, adipocytes, fibroblasts, macrophages, hepatic stellate cells.